Science Inventory

Application of read-across methods as a framework for the estimation of emissions from chemical processes


Takkellapati, S. AND Michael A. Gonzalez. Application of read-across methods as a framework for the estimation of emissions from chemical processes. Clean Technologies and Recycling. AIMS Press, Springfield, MO, 3(4):283-300, (2023).


This product presents an application towards applying read-across and estimation principles when developing generic exposure scenarios for existing and new chemical evaluation. By utilizing existing and developing techniques for read across, within the Chemical Safety for Sustainability research program, this product identifies conditions and needs for applying methods (e.g., read across, prediction, and estimation) for handling data gaps and estimation of a chemical’s physical properties and manufacturing emissions data to populate gaps in EPA’s Office of Pollution Prevention and Toxics’  generic exposure scenario methodology. This approach identifies for the use of required, but non-existent/available data, such as chemical manufacturing emissions, to be quickly obtained and applied by establishing rules; or generalities; for classes of chemicals, categories of use, and properties of chemicals.


The read-across method is a popular data gap filling technique with developed application for multiple purposes, including regulatory. Within the US Environmental Protection Agency's (US EPA) New Chemicals Program under Toxic Substances Control Act (TSCA), read-across has been widely used, as well as within technical guidance published by the Organization for Economic Co-operation and Development, the European Chemicals Agency, and the European Center for Ecotoxicology and Toxicology of Chemicals for filling chemical toxicity data gaps. Under the TSCA New Chemicals Review Program, US EPA is tasked with reviewing proposed new chemical applications prior to commencing commercial manufacturing within or importing into the United States. The primary goal of this review is to identify any unreasonable human health and environmental risks, arising from environmental releases/emissions during manufacturing and the resulting exposure from these environmental releases. The authors propose the application of read-across techniques for the development and use of a framework for estimating the emissions arising during the chemical manufacturing process. This methodology is to utilize available emissions data from a structurally similar analogue chemical or a group of structurally similar chemicals in a chemical family taking into consideration their physicochemical properties under specified chemical process unit operations and conditions. This framework is also designed to apply existing knowledge of read-across principles previously utilized in toxicity estimation for an analogue or category of chemicals and introduced and extended with a concurrent case study.

Record Details:

Product Published Date:12/28/2023
Record Last Revised:02/16/2024
OMB Category:Other
Record ID: 360150