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A New Approach Methodology for the Prediction of Tumorigenesis
Citation:
Ledbetter, V., S. Auerbach, L. Everett, B. Vallanat, A. Lowit, G. Akerman, M. Devito, AND C. Corton. A New Approach Methodology for the Prediction of Tumorigenesis. Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.24450235
Impact/Purpose:
Poster presented to the Society of Toxicology 62nd Annual Meeting and ToxExpo March 2023
Description:
Cancer is the 2nd leading cause of death in the U.S., putting tremendous pressure on the economy. Tens of thousands of chemicals on the market have not been adequately tested for cancer hazard. Testing using the “gold standard” 2-year cancer bioassay is not feasible to fill this data gap. Thus, new approach methodologies (NAMs) are necessary to assess potential carcinogenicity of uncharacterized chemicals. The present study shows how a NAM can be used to identify chemicals and their doses that could cause liver cancer in rats without having to conduct a 2-year bioassay. The NAM uses 6 previously established gene expression biomarkers and tumorigenic activation levels (TALs) to interpret transcript profiles derived from the livers of treated rats. The NAM can identify the chemical mode of action and (non)tumorigenic doses. While this NAM cannot completely replace rodent bioassays, this approach can be used to determine if the 2-year bioassay is necessary potentially reducing cost, time, and resources needed. (This abstract does not represent EPA policy.)
URLs/Downloads:
DOI: A New Approach Methodology for the Prediction of Tumorigenesis
A NEW APPROACH METHODOLOGY (NAM) TO THE PREDICTION OF TUMORIGENESIS_SOT 2023 (44X70).PDF (PDF, NA pp, 610.771 KB, about PDF)