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Characterizing Pathways of Exposure for Risk-Based Chemical Prioritization (ISES 2023)
Citation:
Ring, C., P. Kruse, J. Wambaugh, AND K. Isaacs. Characterizing Pathways of Exposure for Risk-Based Chemical Prioritization (ISES 2023). ISES, Chicago, IL, August 27 - 31, 2023. https://doi.org/10.23645/epacomptox.23968899
Impact/Purpose:
N/A
Description:
We categorized more than 60,000 chemical substances by broad pathways of exposure: consumer, industrial, pesticide, food, pharmaceuticals, and other pathways. These pathway categorizations can be used as a training set for automated read-across of chemical exposure pathways to better inform rapid exposure modeling as part of risk-based chemical prioritization. Pathway categorizations integrated multiple heterogeneous data streams that reported chemical use and/or occurrence. Data streams included large public inventories of chemicals—for example, lists of consumer product ingredients; lists of substances added to food; and lists of pharmaceutical active ingredients as well as government inventories of chemicals with reported use in industrial and consumer sectors. Chemical use and occurrence information from each data stream was organized into 19 harmonized, hierarchical categories for pathways of exposure and 3 aggregated pathways. Each chemical was categorized for each pathway as positive, negative, or unknown (no data), depending on the use/occurrence data available. Using these pathway categorizations, a machine-learning model was trained to predict pathways based on chemical descriptors (such as structure and/or properties). Information about pathways of exposure has been shown to improve the predictive performance of consensus models of human exposure to environmental chemicals and can be applied to inform rapid decision-making about chemical prioritization. The views expressed in this presentation are those of the authors and do not necessarily reflect the views or policies of the U.S. EPA.
URLs/Downloads:
DOI: Characterizing Pathways of Exposure for Risk-Based Chemical Prioritization (ISES 2023)
PRESENTATION.PDF (PDF, NA pp, 2164.418 KB, about PDF)