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Computational (in silico) Cellular Dynamics In Developmental Toxicity (GRC 2023)
Citation:
Knudsen, T. Computational (in silico) Cellular Dynamics In Developmental Toxicity (GRC 2023). Gordon Research Conference (GRC), Andover, NH, August 13 - 18, 2023. https://doi.org/10.23645/epacomptox.24058668
Impact/Purpose:
Presentation to the Gordon Research Conference (GRC) Titled: Cellular & Molecular Mechanisms of Toxicity for Session: “Modern Approaches in Developmental Toxicity Testing” August 2023
Description:
Cellular agent-based models (ABMs) are a novel approach to: (i) visualize cellular trajectories; (ii) map toxicodynamics; and (iii) predict adverse phenotype (cybermorphs). In silico reconstitution of a self-organizing embryo from in vitro data (eg, embryogeny) remains a challenge, and these are theoretical models (artificial life). A fully computable virtual embryo (synbryo) may be a distant goal, but modular systems that bring toxicodynamics to life can pinpoint critical phenomena. Such models would allow a user to simulate limitless ‘what-if’ scenarios quantitatively, similar to computer models used for engineering complex physical systems.
URLs/Downloads:
DOI: Computational (in silico) Cellular Dynamics In Developmental Toxicity (GRC 2023)
GRC_2023_KNUDSEN.PDF (PDF, NA pp, 7559.887 KB, about PDF)