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Development of Uptake Factors for Multi-Route Exposure Assessment Using PBPK Modeling: Trihalomethanes as a Case Study
Citation:
Kenyon, E. Development of Uptake Factors for Multi-Route Exposure Assessment Using PBPK Modeling: Trihalomethanes as a Case Study. Gordon Research Conference, South Hadley, MA, July 30 - August 04, 2023. https://doi.org/10.23645/epacomptox.23721027
Impact/Purpose:
Use of PBPK-derived uptake factors can provide robust estimates of internal exposure across multiple routes and allow consideration of host factors reflecting human variability (e.g., pregnancy, genetic polymorphisms). This research has important implications for exposure assessment in epidemiological studies.
Description:
This presentation will define and present background information on uptake factors and their utility in multi-route exposure assessment, including how they can be derived using a PBPK model, factors that may impact their derivation and implications for exposure assessment and risk analysis.
URLs/Downloads:
DOI: Development of Uptake Factors for Multi-Route Exposure Assessment Using PBPK Modeling: Trihalomethanes as a Case Study
FINAL PRESENTATION.PDF (PDF, NA pp, 483.916 KB, about PDF)