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Validation of Non-Targeted Analysis Methods: Establishing and Communicating Confidence in Results
Citation:
Chao, A., A. Williams, AND J. Sobus. Validation of Non-Targeted Analysis Methods: Establishing and Communicating Confidence in Results. NACRW, Fort Lauderdale, FL, July 25, 2023. https://doi.org/10.23645/epacomptox.23992545
Impact/Purpose:
Presentation on general practices for validating NTA studies in order to promote the standardization of defensible NTA research.
Description:
Targeted analytical methods have long been the standard for monitoring chemicals that may be of significant exposure potential and/or health risk. Given an increasing need to rapidly identify new and data poor contaminants, monitoring approaches have shifted towards discovery- and screening-based methods like non-targeted analysis (NTA) which have a wider scope of chemical coverage. Validation of targeted methods involves demonstrating confidence in the reported results via specific analyses metrics of reference standards. NTA methods often are run without these accompanying standards; as such, validation of these methods is not only a matter of demonstrating confidence in the results, but defining their scope. This talk will cover different approaches brought together in order to “validate” NTA results, including software tools for processing NTA data, databases and applications that provide chemical identity data in lieu of reference standards, and standardization of NTA practices in order to accurately communicate scope and limitations of NTA results. Demonstration of validation of NTA results will be presented on recent exposure monitoring studies performed. This abstract does not necessarily reflect Agency policy.
URLs/Downloads:
DOI: Validation of Non-Targeted Analysis Methods: Establishing and Communicating Confidence in Results
PRESENTATION.PDF (PDF, NA pp, 4067.599 KB, about PDF)