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Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions
Citation:
Wittwehr, C., X. Chang, W. Bisson, S. Edwards, S. Ferguson, A. Harrill, H. Hogberg, A. Karmaus, S. Batista-Leite, E. Lekka, N. Kleinstreuer, K. Markey, A. Masci, M. Mennecozzi, H. Mortensen, J. O'Brien, E. Reinke, C. Schmitt, N. Tucker, AND V. Virvilis. Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions. Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.23564160
Impact/Purpose:
Poster presented to the Society of Toxicology 62nd Annual Meeting and ToxExpo March 2023
Description:
New approach methodologies (NAMs) in biological and computational sciences can generate mechanistic information which can be used to support safety assessments of chemicals. The Adverse outcome pathway (AOP) is a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment. While key events (KE) in an AOP are well-described, users and regulators may not be aware of specific methods for that KE that can be deployed to interrogate chemical-AOP linkages. The Methods2AOP collaboration has been formed to help integrate harmonized, ontologized, annotated methods description fields into the AOP-Wiki to support robust association of methods to MIE and KE. Defining methods that are relevant to defined AOPs can help bolster confidence in the use of NAM data within the AOP framework for regulatory purposes. The Methods2AOP collaborative is actively working to identify minimal information criteria and organization of relevant methods inputs into an approachable, intuitive, and actionable format. This abstract does not reflect US EPA policy.
URLs/Downloads:
DOI: Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions
SOT2023_WITTWEHR_POSTER_METHODS2AOP_FINALFINAL.PDF (PDF, NA pp, 1356.792 KB, about PDF)