You are here:
Vinyl Chloride Enhances High Fat Diet-Induced Proteome Alterations in the Mouse Pancreas Related to Metabolic Dysfunction: Implications for Individual Susceptibility
Citation:
Ge, Y., M. Bruno, M. Nash, AND B. Chorley. Vinyl Chloride Enhances High Fat Diet-Induced Proteome Alterations in the Mouse Pancreas Related to Metabolic Dysfunction: Implications for Individual Susceptibility. Society of Environmental Toxicology and Chemistry SETAC Europe 33rd Annual Meeting, Dublin, N/A, IRELAND, April 30 - May 04, 2023. https://doi.org/10.23645/epacomptox.22798526
Impact/Purpose:
Presentation to the Society of Environmental Toxicology and Chemistry SETAC Europe 33rd Annual Meeting May 2023
Description:
Alterations in physiological processes in pancreas have been associated with various metabolic dysfunctions and can result from environmental exposures, such as chemicals and diet. It was reported that environmental vinyl chloride (VC) exposure, a common industrial organochlorine and environmental pollutant, significantly exacerbated metabolic-related phenotypes in mice concurrently fed high¿fat diet (HFD) but not low-fat diet (LFD). However, little is known about the role of the pancreas in this interplay, especially at a proteomic level. The present study was undertaken to examine the protein responses to VC exposure in pancreas tissues of C57BL/6J mice fed LFD or HFD. We demonstrated that VC-induced pancreas proteome changes were largely linked to metabolic processes in the pancreas that can contribute to diabetes and other facets of metabolic syndrome, such as insulin production and beta cell proliferation e.g., decorin, insulin-like growth factor-1, periostin, phosphorylated protein kinase B (pAKT) and phosphorylated glycogen synthase kinase 3 β. In addition, pancreatic proteins altered by HFD were also augmented by VC exposure compared to mice fed LFD. This result suggested that VC exposed mice might be more sensitive to adverse impacts of HFD. These data suggest that environmental toxicant exposures, such as occupational exposures to VC, may lead to individual susceptibility to adverse metabolic consequences in the pancreas due to dietary choices. (The information in this Abstract has been subjected to review by the Center for Computational Toxicology and Exposure and approved for presentation. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.)
URLs/Downloads:
DOI: Vinyl Chloride Enhances High Fat Diet-Induced Proteome Alterations in the Mouse Pancreas Related to Metabolic Dysfunction: Implications for Individual Susceptibility
05022023 SETAC PLATFORM PRESENTATION_YUE.PDF (PDF, NA pp, 1389.744 KB, about PDF)