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A New Approach Methodology for the Prediction of Tumorigenesis in the Rat (GEMS)
Citation:
Ledbetter, V., S. Auerbach, L. Everett, B. Vallanat, A. Lowit, G. Akerman, M. Devito, AND C. Corton. A New Approach Methodology for the Prediction of Tumorigenesis in the Rat (GEMS). Genetics and Environmental Mutagenesis Society Meeting, RTP, NC, November 01, 2022. https://doi.org/10.23645/epacomptox.23502141
Impact/Purpose:
Poster presented to the Genetics and Environmental Mutagenesis Society meeting Nov 2022
Description:
Cancer is the 2nd leading cause of death in the U.S., putting tremendous pressure on the economy. Tens of thousands of chemicals on the market have not been adequately tested for cancer hazard. Testing using the “gold standard” 2-year cancer bioassay is not feasible to fill this data gap. Thus, new approach methodologies (NAMs) are necessary to assess potential carcinogenicity of uncharacterized chemicals. The present study shows how a NAM can be used to identify chemicals and their doses that could cause liver cancer in rats without having to conduct a 2-year bioassay. The NAM uses 6 previously established gene expression biomarkers and tumorigenic activation levels (TALs) to interpret transcript profiles derived from the livers of treated rats. The NAM can identify the chemical mode of action and (non)tumorigenic doses. While this NAM cannot completely replace rodent bioassays, this approach can be used to determine if the 2-year bioassay is necessary potentially reducing cost, time, and resources needed. (This abstract does not represent EPA policy.)
URLs/Downloads:
DOI: A New Approach Methodology for the Prediction of Tumorigenesis in the Rat (GEMS)
LEDBETTER_POSTER_A NEW APPROACH METHODOLOGY (NAM) TO THE PREDICTION OF TUMORIGENESIS_2022_10_16_22.PDF (PDF, NA pp, 720.961 KB, about PDF)