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Incorporating neuroendocrine mechanisms and resiliency in assessing air pollution health effects
Citation:
Kodavanti, U. Incorporating neuroendocrine mechanisms and resiliency in assessing air pollution health effects. International Particle Toxicological Conference (IPTC), Santa Fe, NM, August 27 - 31, 2022.
Impact/Purpose:
Lung does not work in isolation when responding to encountered air pollutants. Acute effects are dependent on pollutant reactivity and mechanistically linked to neuroendocrine stress pathways
Description:
Considering neuroendocrine stress response in PM studies. Neuroendocrine stress response is an acute reaction to exposure/less stress - which we generally referred as toxicity - for inhaled pollutants producing respiratory, neural and peripheral effects, likely inseparable from chronic response. Neuroendocrine response to reactive air pollutant exposure is dynamic and regulated by adrenal-derived stress hormones. This response is plastic, thus linked to adaptation/habituation/ resiliency and involves adrenal-derived glucocorticoids – allostatic load.