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Physiologically Based Pharmacokinetic (PBPK) Modeling Contaminants of Concern in Drinking Water
Citation:
Kenyon, E. Physiologically Based Pharmacokinetic (PBPK) Modeling Contaminants of Concern in Drinking Water. American College of Toxicology, Phoenix, AZ, November 17 - 20, 2019. https://doi.org/10.23645/epacomptox.22572697
Impact/Purpose:
Physiologically-based pharmacokinetic (PBPK) models are well-accepted tools used to perform scientifically sound risk analysis for multiple applications including exposure route extrapolation, exposure scenario extrapolation, and cross-species extrapolation.
Description:
Physiologically-based pharmacokinetic (PBPK) models are a well-accepted tool used by regulatory agencies for multiple risk assessment applications. These applications include exposure route extrapolation, exposure scenario extrapolation, and cross-species extrapolation. All of these extrapolation areas are key to performing credible, scientifically sound human health risk assessment and all are frequently performed in the process of developing health-protective exposure limits for pollutants in multiple media. In this talk, the utility of PBPK modeling will be illustrated using bromodichloromethane, a drinking water disinfection byproduct, as a case study. This model has multiple risk analysis applications, including multi-route exposure assessment, prediction of toxicity based on internal dose to target tissues, risk analysis for potentially susceptible sub-populations, and prediction of the effect(s) of changes in disinfection scenarios on tissue dosimetry and toxicity.
URLs/Downloads:
DOI: Physiologically Based Pharmacokinetic (PBPK) Modeling Contaminants of Concern in Drinking Water
ACT_AM19_KENYONDRINKINGWATERPBPK.PDF (PDF, NA pp, 3015.792 KB, about PDF)