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Transcriptomics-based points of departure for ecotoxicology – an update (APCRA)
Citation:
Villeneuve, D. Transcriptomics-based points of departure for ecotoxicology – an update (APCRA). Advancing the Pace of Chemical Risk Assessment (APCRA) Meeting, NA, MN, November 10, 2022. https://doi.org/10.23645/epacomptox.21603354
Impact/Purpose:
High throughput assays that incorporate global gene expression measurements have been proposed as a cost effective way to provide broad pathway coverage in chemical safety screening. To date, high throughput transcriptomic assays with human cell lines have been implemented. However, even with coverage of the whole human transcriptome, there are many biological pathways and functions for other organisms that are not represented. The current research is a case study on the use of a transcriptomics-based high throughput assay with larval fathead minnows as a basis for ecological hazard screening. Results were generated for 22 chemicals and assay performance evaluated. Data generated help to inform further development and optimization of ecologically-focused high throughput transcriptomic assays. The current presentation reports on our research to Accelerating the Pace of Chemical Risk Assessment as an international consortium focused on implementation of NAMs in regulatory chemical safety evaluation.
Description:
The attached presentation provides an update on a case study for Accelerating the Pace of Chemical Risk Assessment (APCRA). This update will be presented at an APCRA teleconference to be held November 10, 2022.
URLs/Downloads:
DOI: Transcriptomics-based points of departure for ecotoxicology – an update (APCRA)
APCRA 2022_VILLENEUVE_ECOHTTR_V2.PDF (PDF, NA pp, 2160.877 KB, about PDF)