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COMPARATIVE MICROCYSTIN CONGENERS TOXICITY RESEARCH SUMMARY
Citation:
Hill, D. AND N. Chernoff. COMPARATIVE MICROCYSTIN CONGENERS TOXICITY RESEARCH SUMMARY. Presentation to the HABHRCA ( Harmful Algal Bloom and Hypoxia Research and Control Amendments Act) Interagency Working Group, NA-Virtual, NC, December 02, 2021.
Impact/Purpose:
This presentation summarizes research on microcystins, the most common type of cyanotoxins in US freshwaters. It is a contaminant of concern in drinking and recreational freshwater. This information informs risk assessors and regulators of potential effects for human health by demostrating the toxicity of ten microcystin congeners given orally in the mouse.
Description:
This presentation summarizes research on microcystins, the most common type of cyanotoxins in US freshwaters. It is a contaminant of concern in drinking and recreational freshwater. This information informs risk assessors and regulators of potential effects for human health by demostrating the toxicity of ten microcystin congeners given orally in the mouse. The toxins were given as a single oral dose at 7mg/kg to compare toxicity between congeners as well as an additional study which determined NOAELs (no observable adverse effect level) and LOAELs (lowest observable adverse affect level) of a single dose of five of the most common congeners in the US.