You are here:
Developing a Conceptual Scientific Workflow to Estimate Chemical Exposures (ISES)
Citation:
Vallero, Dan, C. Dalton, AND E. Hubal. Developing a Conceptual Scientific Workflow to Estimate Chemical Exposures (ISES). ISES, Lisbon, PORTUGAL, September 25 - 29, 2022. https://doi.org/10.23645/epacomptox.21183370
Impact/Purpose:
N/A
Description:
Holistic evaluation of chemical impacts requires integration of disparate data streams, modeling of interactions among physical and biological systems, and consideration of tradeoffs associated with management decisions. Environmental health scientists have developed a variety of models that use available data with other mechanistic information to understand how chemicals in products move through the natural and built environment. Each new problem incrementally advances data, models, and understanding. To efficiently address problems of increasing complexity and enable greater insights, more nimble modeling methodologies are required to assess important chemical exposure scenarios and pathways across the chemical/product lifecycle. A scientific workflow is designed to execute a series of data manipulation and computational steps to provide outputs tailored to decision-making contexts. For chemical assessments, scientific workflows are useful tools for efficient and transparent analyses, especially for considering impacts in complex systems. To demonstrate this approach, relatively data-rich chemicals will be used as test cases for efficient evaluation of a variety of chemicals and a range of decision contexts. A recently developed workflow uses customized algorithm, data, and model selection to estimate aggregate exposures to PFAS for regulatory decision-making and other exposure characterization efforts. PFAS exposure estimates to date have had high levels of uncertainty because they are present in myriad products and exposure scenarios, routes, and pathways. Credible risk assessments and regulatory actions are not possible without sound and proven exposure tools and reliable data. This symposium will discuss the ongoing research that is bridging knowledge gaps in data-poor compounds, especially PFAS.
URLs/Downloads:
DOI: Developing a Conceptual Scientific Workflow to Estimate Chemical Exposures (ISES)
ISES WORKFLOW DAV ET AL FINAL.PDF (PDF, NA pp, 1694.119 KB, about PDF)