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PubMed Abstract Sifter: a literature informatics tool for chemical research
Citation:
Baker, N. PubMed Abstract Sifter: a literature informatics tool for chemical research. Fall ACS, Chicago, IL, August 21 - 25, 2022. https://doi.org/10.23645/epacomptox.20490168
Impact/Purpose:
The increasing rate of production and release of new chemicals into commerce requires improved access to experimental and predicted toxicity and property data, the ability to rapidly assess chemical alternatives for hazard, and the ability to prioritize chemicals for testing. This symposium covers topics including tools to estimate toxicity and properties, tools for rapidly evaluating hazard and/or risk, and automated workflows for developing curated data sets and QSAR models.
Description:
Even with the increase in chemical data in structured databases, a large portion of what is known about chemical toxicity remains in the unstructured text of the biomedical literature. Assessing toxicity or potential toxicity of a chemical requires reviewing this literature. The EPA’s PubMed Abstract Sifter implements rich APIs in a dynamic Excel front end to allow the researcher to retrieve the literature for a set of chemicals (and their proposed alternatives) and explore that literature, takes notes and triage the citations, and also rank chemicals on the strength of their literature ties to toxicity types (e.g., genetic toxicity, reproductive toxicity, etc.) The Abstract Sifter version 7 introduces the capability to extract substance names from the returned citations to build a chemical set of compounds for evaluation. The resulting chemical set can be integrated automatically with identifiers and data from the EPA’s Chemical dashboard. The Dashboard and the Abstract Sifter are available at comptox.epa.gov. This abstract does not necessarily represent US EPA policy.
URLs/Downloads:
DOI: PubMed Abstract Sifter: a literature informatics tool for chemical research
ACS_BAKER_ENVR.PDF (PDF, NA pp, 1712.965 KB, about PDF)