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Uncovering chemical toxicity by high-throughput transcript profiling: linking molecular targets to potential adverse effects
Citation:
Corton, C. Uncovering chemical toxicity by high-throughput transcript profiling: linking molecular targets to potential adverse effects. Physicians Committee for Responsible Medicine Summer School on Innovative Approaches in Science, Durham, NC, June 09, 2022. https://doi.org/10.23645/epacomptox.20134379
Impact/Purpose:
Presentation to students taking summer courses at the Physicians Committee for Responsible Medicine Summer School on Innovative Approaches in Science Meeting June 2022.
Description:
There is no abstract associated with this talk. However there are a number of objectives: •How high-throughput transcript profiling is carried out as a method to comprehensively assess the effects of chemicals on biological systems •Different platforms for assessing genome scale gene expression changes •High-throughput transcript profiling (HTTr) • •How to identify the molecular targets of chemicals •Hypothesis generating tools •Gene expression biomarkers •How to •Identify predictive gene sets •Characterize the gene sets •Determine predictive accuracy •Use in screening chemicals •How to link the alterations in molecular targets to potential adverse events. •Use of the adverse outcome framework
URLs/Downloads:
DOI: Uncovering chemical toxicity by high-throughput transcript profiling: linking molecular targets to potential adverse effects
CORTON_SUMMERSCHOOL_JUNE_2022.PDF (PDF, NA pp, 6424.478 KB, about PDF)