Science Inventory

Abstract Sifter: A literature informatics tool for chemical safety assessments (ASCCT 2020)

Citation:

Baker, Nancy C. AND T. Knudsen. Abstract Sifter: A literature informatics tool for chemical safety assessments (ASCCT 2020). American Society for Cellular and Computational Toxicology (ASCCT) Annual Meeting, NA (Virtual), NC, October 19 - 21, 2020. https://doi.org/10.23645/epacomptox.17118737

Impact/Purpose:

Poster presented to the American Society for Cellular and Computational Toxicology (ASCCT) Annual Meeting October 2020

Description:

By the year 2035, the US EPA aims to eliminate animal testing in chemical safety assessment by adopting a set of new approach methods (NAMs). These methods will rely on rich data and an understanding of the mechanisms underpinning chemical toxicity. The biomedical literature is a rich source of information about mechanisms of toxicity, but because resources like PubMed are so large and complex, literature informatics methods are needed to help researchers use this resource more effectively. We have developed a freely available Excel-based literature tool called the Abstract Sifter to retrieve and triage articles and to visualize the literature landscape for a set of chemicals. The tool is supplied with queries that facilitate exploration of mechanistic information by using the language of Adverse Outcome Pathways (AOPs) and Key Characteristics of Carcinogens.  

Record Details:

Record Type: DOCUMENT ( PRESENTATION/ POSTER)
Product Published Date: 10/21/2020
Record Last Revised: 12/02/2021
OMB Category: Other
Record ID: 353500