You are here:
Transcriptomics-based points of departure for ecotoxicology – an update
Citation:
Villeneuve, Dan. Transcriptomics-based points of departure for ecotoxicology – an update. Accelerating the pace of chemical risk assessment (APCRA), Duluth, MN, October 14 - 15, 2021. https://doi.org/10.23645/epacomptox.16814737
Impact/Purpose:
A growing body of literature in chemical safety assessment for human health suggest that concentration-response modeling of whole transcriptome responses following short-term exposures can yield toxicological points of departure similar to those determined in long-term in vivo studies. However, the potential uses of transcriptomics-based points of departure (tPOD) and high throughput assays for evaluating ecological toxicity has not been explored. This presentation provides a work in progress update on a case study that employed 24 h, high throughput assays with larval fathead minnows to generate a tPOD for 10 chemicals. Resulting tPODs were compared with toxicological effect concentrations from traditional in vivo testing as well as new approach methodologies like ToxCast. Additionally, in silico sub-sampling of the data were used to further optimize the high throughput assay design and identify key variables that could serve as assay acceptance criteria. This research is aimed to providing high throughput tools for ecological chemical safety assessments to complement those being developed and implemented for human health evaluations.
Description:
No abstract associated with this presentation
URLs/Downloads:
DOI: Transcriptomics-based points of departure for ecotoxicology – an update
APCRA 2021_VILLENEUVE_ECOHTTR_V3.PDF (PDF, NA pp, 3375.245 KB, about PDF)