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APCRA Case Study:High Throughput Toxicokinetics for In Vitro-In Vivo Extrapolation
Citation:
Wambaugh, J., T. Barton-Maclaren, M. Beal, M. Devito, J. Dorne, S. Ferguson, M. Hughes, R. Judson, I. Moffat, A. Nong, A. Paini, K. Paul-Friedman, R. Thomas, AND B. Wetmore. APCRA Case Study:High Throughput Toxicokinetics for In Vitro-In Vivo Extrapolation. Accelerating the Pace of Chemical Risk Assessment (APCRA) meeting, Virtual, NC, October 14 - 15, 2021. https://doi.org/10.23645/epacomptox.16828510
Impact/Purpose:
Presentation to the Accelerating the Pace of Chemical Risk Assessment (APCRA) meeting October 2021
Description:
We aim to demonstrate that High Throughput Toxicokinetics (HTTK), with appropriately propagated uncertainty, enhances NAM-based prediction of in vivo points of departure to inform regulatory decision making. We will describe a framework for decision makers to make use of toxicokinetic (TK) new approach methods that take into consideration chemical space and the decision-making context. We will provide a series of case studies as examples for applying this framework. We also include a review of in vitro-measured TK parameters and in vivo TK data curated from the literature. In addition, we review the quantitative uncertainty in HTTK-based predictions of toxicokinetics. Finally, we will perform a gap analysis by identifying, for example, areas of chemical space and routes of exposure in need of further research. This does not reflect EPA policy.
URLs/Downloads:
DOI: APCRA Case Study:High Throughput Toxicokinetics for In Vitro-In Vivo Extrapolation
WAMBAUGH APCRA-HTTKCASESTUDY-OCTOBER2021UPDATE-DRAFT5.PDF (PDF, NA pp, 2819.82 KB, about PDF)