You are here:
Source-to-Dose: A Component in the Combined Human Exposure Model
Citation:
Fisher, H., A. East, AND Dan Vallero. Source-to-Dose: A Component in the Combined Human Exposure Model. 2021 ISES Annual Meeting (Virtual), Durham, North Carolina, August 30 - September 02, 2021. https://doi.org/10.23645/epacomptox.15157644
Impact/Purpose:
Limited data are available to assess potential chemical risks to humans from manufacture, use, and disposal of consumer products and articles. Tools are needed to access and leverage available data on chemical manufacture, use, and occurrence for important chemical exposure scenarios and pathways across the product lifecycle. Scientific workflows are designed to execute a series of computational or data manipulation steps. The simplest automated scientific workflows are scripts that call in data, models, and other inputs and produce outputs that may include analytical results and visualizations. The value of using this approach is that domain-specific data types and tools can be made available to the exposure scientist and easily accessible to the exposure assessor for specific decision contexts. This product provides regulatory scientists, students and researchers with the ability to effectively access and exploit the many in silico data streams to support different regulatory purposes and supports current Agency efforts to reduce mammal study requests by 30% by 2025, and completely eliminate all mammal study requests and funding by 2035
Description:
The Source-to-Dose module in the CHEM suite calculates estimated exposures over the course of a year for the sample population. This is done by taking in a simulated population, such as the one created with RPGen, and a product use diary, such as the one created with Product Use Scheduler, and determining how much exposure can be expected from each product that is used, essentially taking the list of sources and converting it into a longitudinal assessment of estimated exposure for each individual. These longitudinal calculations can account for both compounding effects, such as reapplication before the effects of the previous use have dissipated, and lasting effects, such as an aerosol that lingers in the air for weeks, resulting in continuously smaller, though still non-zero, exposures for the entire period. Recent additions to Source-to-Dose include calculations for exposure due to diet and articles. We intend to further develop the dietary section to more accurately model effects of water contamination on a population, specifically with the 1,4-Dioxane case study in mind.
URLs/Downloads:
DOI: Source-to-Dose: A Component in the Combined Human Exposure Model
ORD-042001_SLIDES ISES.PDF (PDF, NA pp, 705.697 KB, about PDF)