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Male reproductive toxicity in animal studies of diisobutyl phthalate (DIBP): a case study application of systematic review approaches-Poster
Citation:
Yost, E., S. Euling, J. Weaver, B. Beverly, Nagalakshmi Keshava, A. Mudipalli, X. Arzuaga Andino, T. Blessinger, L. Dishaw, A. Hotchkiss, AND S. Makris. Male reproductive toxicity in animal studies of diisobutyl phthalate (DIBP): a case study application of systematic review approaches-Poster. US EPA Board of Scientific Counselors Chemical Safety Subcommittee Meeting, Research Triangle Park, NC, April 10 - 12, 2019.
Impact/Purpose:
This poster depicts the workflow used by the Integrated Risk Information System program for the systematic review of animal studies.
Description:
Systematic review plays an important role in enhancing the transparency and confidence in scientific assessments. HHRA is developing innovative workflow methods and processes for implementing systematic review across its portfolio of assessment products. Case studies are presented to highlight the advancements in systematic review throughout assessment development. The Integrated Risk Information System (IRIS) performed a systematic review of male reproductive effects of DIBP exposure that considered any outcomes indicative of male reproductive toxicity and all life stages of exposure, following recommendations in the 2014 National Academy of Sciences (NAS) review of the IRIS program. Here, we use studies that evaluated testosterone in male rodents exposed to DIBP or MIBP as a case study of the IRIS systematic review process. We also summarize the overall conclusions for male reproductive effects identified in the IRIS systematic review of DIBP.