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Ex Priori: A Screening-Level Chemical Prioritization Dashboard for Consumer Exposures
Citation:
Goldsmith, M., C. Ring, H. Hubbard, T. Hong, C. Henning, Dan Vallero, AND P. Egeghy. Ex Priori: A Screening-Level Chemical Prioritization Dashboard for Consumer Exposures. Society of Toxicology 2021 Virtual Annual meeting, Virtual, NC, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14489196
Impact/Purpose:
Poster presented to the Society of Toxicology annual meeting March 2021.
Description:
“If these are the things I do and the products I use, then to which chemicals am I being exposed?” Exposure to a wide range of chemicals through our daily habits and routines and interaction with consumer products is ubiquitous and largely unavoidable. Due to the breadth of consumer product formulations of chemical ingredients and the diversity of consumer-specific habits and practices the task of quantifying one’s chemical exposure profile can be daunting, if not overwhelming. The U.S. EPA's Exposure Prioritization (Ex Priori) tool is a simplified, quantitative visual dashboard that makes use of data from various inputs to provide rank-ordered internalized dose-metric and to address the very question of one’s personal chemical exposure to all chemicals in consumer products. Developed as a flexible dashboard-type chemical prioritization tool, Ex Priori was intended to complement other more data- and compute-intensive, population-based exposure models. A key focus of its design was to provide a scenario-specific ranking of multiple chemical exposures from consumer products while accounting for physico-chemical properties (e.g., partitioning coefficients); exposure factors; and variations in product formulations, activity patterns, and product use profiles (e.g. habits and practices). Additionally, Ex Priori extends traditional exposure models by incorporating chemical-specific predictions of absorption, distribution, metabolism, and excretion (ADME) processes to estimate route- and chemical-specific internal doses. Ultimately, Ex Priori translates personal chemical exposure from seven exposure pathways for 1634 chemicals present in 228 consumer product categories to a rank-ordered interactive visual representation of body burden. These pathways are: 1. Airborne-direct inhalation; 2. Airborne-indirect gas inhalation; 3. Airborne- indirect particle inhalation; 4. Direct dermal permeability; 5. Incidental indirect ingestion; 6. Indirect hand-to-mouth ingestion; and, 7. Indirect surface resuspension ingestion . Finally, Ex Priori contains controls (i.e., sliders) to vary user-specific activity, in addition to tables of habits/practice assumptions of which products are likely to be in specific microenvironments and how often these products are used. These assumptions can be updated by the user to account for particular exposures such as hobbyist or occupational users who have higher exposure potential. By adjusting Ex Priori controls for different scenarios, all 1634 consumer product chemical ingredients are simultaneously reprioritized on anticipated body-burden, enabling a fast representation of one’s day-to-day personal multi-chemical exposures from consumer products. [ This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.]
URLs/Downloads:
DOI: Ex Priori: A Screening-Level Chemical Prioritization Dashboard for Consumer Exposures
SOT_EXPRIORI_POSTER_GOLDSMITH_02042021.PDF (PDF, NA pp, 1471.065 KB, about PDF)