You are here:
Predicting Chromatography-tandem Mass Spectrometry Amenability to Improve Non-targeted Analysis (Agilent)
Citation:
Lowe, C., K. Isaacs, A. McEachran, Chris Grulke, J. Sobus, E. Ulrich, A. Chao, AND A. Williams. Predicting Chromatography-tandem Mass Spectrometry Amenability to Improve Non-targeted Analysis (Agilent). Agilent Online Webinar, Virtual, NC, February 26, 2021. https://doi.org/10.23645/epacomptox.14188553
Impact/Purpose:
Presentation to Agilent Online Webinar February 2021
Description:
Non-targeted analysis (NTA) strives to detect and identify a wide range of chemicals without preconceived target list or standards. Such efforts can be applied to and use a variety of exposure science efforts, including basic research into the technique (ENTACT), informatics tools (CompTox Chemicals Dashboard), complex mixtures (UVCBs) and pairing exposure to effects (EDA). Approximately 30 laboratories worldwide are characterizing their non-targeted analysis approaches. Because the instrumental and data processing methods vary significantly, so do performance metrics. Physicochemical properties are statistically different between instrumental method choices (gas vs. liquid chromatography, electrospray vs. atmospheric pressure chemical ionization) showing the techniques cover different portions of chemical space. Current and future NTA research areas are also linked to larger scientific efforts within the exposure community at EPA.
URLs/Downloads:
DOI: Predicting Chromatography-tandem Mass Spectrometry Amenability to Improve Non-targeted Analysis (Agilent)
LOWE_AMENABILITY_AGILENT_DRAFT.PDF (PDF, NA pp, 2826.053 KB, about PDF)