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miRror, miRror: the biofluid-based biomarker reflective of biological effect
Citation:
Chorley, B. miRror, miRror: the biofluid-based biomarker reflective of biological effect. October meeting for NIH Circulating Nucleic Acids/Liquid Biopsy (CNA/LB) Scientific Interest Group, Virtual meeting, NC, October 13, 2020. https://doi.org/10.23645/epacomptox.13376000
Impact/Purpose:
The talk will be given to the NIH Circulating Nucleic Acids Workgroup, whose overall interest is to discuss ongoing studies focused on using measurable nucleic fluids in biofluids that are indicative of adverse health outcomes. My talk will give an overview of recent studies performed in the lab and in collaboration with others that highlight the advantages of measuring microRNA in tissues and in biofluids that can be indicative for toxicity. These Novel Approach Methods can reduce the amount of rodent studies needed to assess chemical mediated mode-of-action for regulatory based screening and weight-of-evidence.
Description:
This presentation will go over recent collaborative work in the lab that describes 1) the dose-responsiveness of microRNA in rodent liver in response to chemical exposure 2) the release of microRNA into biofluid in response to regional tissue toxicity in a rodent model, and 3) the alteration of circulatory miRNAs in response to probable disease state due to environmental chemical exposures in a human residential cohort. The talk will go over both the advantages of these novel biomarkers, as well as the challenges that we face to developed these for regulatory and other toxicological uses.
URLs/Downloads:
DOI: miRror, miRror: the biofluid-based biomarker reflective of biological effect
201012_NIH_CNA_LB TALK_CHORLEY V2.PDF (PDF, NA pp, 4742.75 KB, about PDF)