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Revisiting and updating chemical groupings with new approach methodologies
Citation:
Chang, D., K. Fay, K. Markey, M. Phillips, G. Patlewicz, A. Richard, L. Scarano, Mahmoud A. Shobair, R. Lougee, E. Saluck, J. Prindiville, C. Inglis, M. Lewis, AND K. Mansouri. Revisiting and updating chemical groupings with new approach methodologies. APCRA-5 Virtual Teleconference (Accelerating the Pace of Chemical Risk Assessment), Virtual, Virtual, August 26 - 27, 2020. https://doi.org/10.23645/epacomptox.13268963
Impact/Purpose:
This work seeks to address the problem of integration, use and application of NAMs in a regulatory setting supporting TSCA efforts and the TSCA Alternative Testing Strategy. Furthermore, this work seeks to develop a systematic method/workflow to incorporate NAM data into category development. Findings from this work will potentially influence how program office partners and the international community can use NAM information (both in silico and in vitro) to develop chemical categories pes. with regards to data poor chemistry domains. Current work includes collaboration with program office (OPPT and OSCP) as well as international partners (Canada) as part of the larger international APCRA workgroup effort.
Description:
Presentation to be given to the Accelerating the Pace of Chemical Risk Assessment (APCRA) virtual teleconference in August 2020. This work seeks to address the problem of integration, use and application of NAMs in a regulatory setting supporting TSCA efforts and the TSCA Alternative Testing Strategy. Furthermore, this work seeks to develop a systematic method/workflow to incorporate NAM data into category development. Findings from this work will potentially influence how program office partners and the international community can use NAM information (both in silico and in vitro) to develop chemical categories pes. with regards to data poor chemistry domains. Current work includes collaboration with program office (OPPT and OSCP) as well as international partners (Canada) as part of the larger international APCRA workgroup effort.
URLs/Downloads:
DOI: Revisiting and updating chemical groupings with new approach methodologies
CHANG DDG_APCRA_08242020.PDF (PDF, NA pp, 1500.651 KB, about PDF)