You are here:
Method 559: Determination of Nonylphenol and 4-tert-Octylphenol in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Citation:
Tettenhorst, D. AND J. Shoemaker. Method 559: Determination of Nonylphenol and 4-tert-Octylphenol in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS). U.S. Environmental Protection Agency, Washington, DC, 2020.
Impact/Purpose:
EPA Method 559 may be used in a future UCMR to gather nationwide occurrence data on nonylphenol and 4-tert-octylphenol and may be used by environmental laboratories to quantitate these chemicals in drinking water.
Description:
Method 559 is an accurate and precise analytical method to determine nonylphenol and 4-tert-octylphenol in drinking water using solid phase extraction and liquid chromatography tandem mass spectrometry (SPE-LC/MS/MS). This method development task establishes sample preservation techniques, sample concentration and analytical procedures, aqueous and extract holding time criteria and quality control procedures. Draft Method 559 has undergone a multi-laboratory verification to ensure other laboratories can implement the method and achieve the quality control measures specified in the method.