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Tox21BodyMap: A webtool to map chemical effects on the human body
Citation:
Borrel, A., S. Auerbach, K. Houck, AND N. Kleinstreuer. Tox21BodyMap: A webtool to map chemical effects on the human body. NUCLEIC ACIDS RESEARCH. Oxford University Press, Cary, NC, 48(W1):W472-W476, (2020). https://doi.org/10.1093/nar/gkaa433
Impact/Purpose:
Development of webtool to allow identification of tissues in the human body expressing the targets of Tox21 high-throughput screening assays. Such information suggest potential sites of bioactivity/toxicity in the human.
Description:
To support rapid chemical toxicity assessment and mechanistic hypothesis generation, here we present an intuitive webtool allowing a user to identify target tissues in the human body where a substance is estimated to be more likely to produce effects. This tool, called Tox21BodyMap, incorporates results of 9,270 chemicals tested in the U.S. federal Tox21 research consortium in 971 high-throughput screening (HTS) assays whose targets were mapped onto human organs using tissue-specific gene expression data. Via Tox21BodyMap’s interactive tools, users can visualize chemical target specificity by organ system, and implement different filtering criteria by changing gene expression thresholds and activity concentration parameters. Dynamic network representations, data tables, and plots with comprehensive activity summaries across all Tox21 HTS assay targets provide an overall picture of chemical bioactivity. Tox21BodyMap webserver is available at https://sandbox.ntp.niehs.nih.gov/bodymap/.
URLs/Downloads:
DOI: Tox21BodyMap: A webtool to map chemical effects on the human body
https://pubmed.ncbi.nlm.nih.gov/32491175/