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The Chemical Landscape of New Approach Methodologies for Exposure
Citation:
Isaacs, K. The Chemical Landscape of New Approach Methodologies for Exposure. Accelerating the Pace of Chemical Risk Assessment Workgroup Meeting, Durham, NC, July 12, 1905. https://doi.org/10.23645/epacomptox.12551342
Impact/Purpose:
This presentation will be presented via a public webinar showcasing case studies from the Accelerating the Pace of Chemical Risk Assessment workgroup. The talk covers an exposure-focused case study exploring the chemical coverage of regulatory inventories of exposure New Approach Methods.
Description:
New approach methodologies (NAM) for assessing chemical hazard are now established, and are being evaluated for inclusion in regulatory decision-making strategies. However, to implement true risk-based decision-making, analogous methods for assessing exposure potential are needed to provide real-world context to high-throughput (HT) hazard data. Under EPA’s ExpoCast project, HT in silico exposure NAMs have been developed for predicting relevant data (e.g., chemical use and release, environmental and biological concentrations, toxicokinetic parameters, and ultimately exposures) in support of risk-based decision making.
URLs/Downloads:
DOI: The Chemical Landscape of New Approach Methodologies for Exposure
ISAACS_APCRA_LANDSCAPE_03102020.PDF (PDF, NA pp, 1307.718 KB, about PDF)