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Multi-method assessment of PVP-coated silver nanoparticles and artificial sweat mixtures (journal)
Citation:
Peloquin, D., E. Baumann Jr., AND Todd P. Luxton. Multi-method assessment of PVP-coated silver nanoparticles and artificial sweat mixtures (journal). CHEMOSPHERE. Elsevier Science Ltd, New York, NY, 249:126173, (2020). https://doi.org/10.1016/j.chemosphere.2020.126173
Impact/Purpose:
The Office of Chemical Safety and Pollution Prevention (OCSPP) is tasked with reviewing premanufacturing notices for chemicals, and more recently materials, that include engineered nanomaterials under the Frank R. Lautenberg Chemical Safety for the 21st Century Act. Engineered nanomaterials (ENM) represent a class of materials with particle sizes between 1 and 100 nm. Often these materials exhibit chemical and physical behaviors that differ from the properties of larger particles. Due to the unique properties associated with these materials current approved methods and practices for evaluating the exposure potential are incomplete or not appropriate for use. Further, there are often numerous methods and analytical techniques used in the scientific literature to quantify exposure with each providing very different results based on the method and analytical technique employed. The current research effort is intended to provide insight into how results from different methods vary and how the specific analytical technique used to measure/monitor exposure can influence the outcome and the overall results of an exposure assessment.
Description:
Research presented here utilizes silver nanoparticles (AgNPs) as a case study for how the immediate local environment alters the physical and chemical properties of nanomaterials. Dermal exposure is a primary route for exposure to many of the consumer products containing AgNPs. Interactions between AgNPs and human sweat/perspiration are critical for understanding how changes in Ag speciation will impact exposure. Previous studies have examined silver release from AgNP-containing products after exposure to artificial sweat (AS), however there is no basic assessment of how mixtures of AgNPs and AS alter the physical and chemical properties of AgNPs. The current research evaluated changes in size, aggregation, chemical composition, and silver speciation of four different sizes of AgNPs exposed to four different formulations of AS. The AS formulations were from standardized methods with different chemical compositions, ionic strengths, and pH. Samples were collected at four-time intervals for analysis using dynamic light scattering , UV–Vis spectroscopy, and single-particle inductively coupled plasma-mass spectrometry . Each mixture was also prepared for speciation analysis using X-ray absorption spectroscopy and scanning electron microscopy coupled to energy-dispersive X-ray analysis. The equivalent diameter measurements from the three techniques followed the order of DLS > UV–Vis > spICP-MS. Speciation analyses indicate significant changes for the smaller NPs, while the largest (100 nm) NPs had less measurable differences. This study shows the need to fully understand what specific information an analytical technique might provide and to use those techniques properly in tandem to give the fullest answer to a given research question.
URLs/Downloads:
DOI: Multi-method assessment of PVP-coated silver nanoparticles and artificial sweat mixtures (journal)
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