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20181114 - In Silico Dynamic Models for Developmental Toxicity (FutureTox)
Citation:
Knudsen, T. 20181114 - In Silico Dynamic Models for Developmental Toxicity (FutureTox). FutureTox IV conference, Crystal City, VA, November 14 - 16, 2018.
Impact/Purpose:
Abstract submitted to FutureTox IV conference in November 2018. The concept of testing a ‘virtual embryo’ will be demonstrated utilizing case studies tying the in vitro data and in silico models to fundamental principles of teratogenesis.
Description:
Computer modeling and simulation of complex dynamical systems can provide a virtual framework for translating biomolecular lesions into critical phenomena underlying developmental processes and toxicities. In silico cell agent-based models (ABMs) may be executed to simulate how biomolecular lesions from in vitro HTS datasets (ToxCast) might propagate through a morphogenetic series of events to yield an adverse effect based on current theory as to molecular pathways and cellular processes that drive human embryology and development. The concept of testing a ‘virtual embryo’ will be demonstrated utilizing case studies tying the in vitro data and in silico models to fundamental principles of teratogenesis. This work does not reflect EPA policy.