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Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse
Citation:
Bradham, K., C. Nelson, G. Diamond, W. Thayer, Kirk G. Scheckel, Matthew Noerpel, K. Herbin-Davis, B. Elek, AND D. Thomas. Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 53(21):12556-12564, (2019). https://doi.org/10.1021/acs.est.9b02803
Impact/Purpose:
This study evaluated the influence of dietary phosphate on lead bioavailability using an in vivo mouse model. A better understanding of the influence of phosphate on lead is necessary for development and use of soil remediation technologies that often use phosphate to bind lead with the aim of reducing the lead bioavailability.
Description:
Effects of dietary P level on the oral bioavailability of Pb present in soil were examined in a mouse model. Adult female C57BL/6 mice had free access to AIN-93G purified rodent diet amended with Pb as a soluble salt, Pb acetate, or in a soil matrix (NIST SRM 2710a). Diets used in these studies contained P at a nutritionally sufficient level (0.3% w/w) or at a higher (1.2%) or a lower level (0.15%). For either dietary Pb source (Pb acetate or NIST SRM 2710a), low dietary P level markedly increased accumulation of Pb in bone, blood, and kidney. Tissue Pb levels in mice fed a high P in diet were not different from mice fed the basal P diet. Dietary P and Pb interacted to affect body weight change and feed efficiency in mice. The relative contribution of different Pb species in diet and feces was also affected by dietary P level. Differences in Pb species between diet and feces indicated that transformation of Pb species can occur during gastrointestinal tract transit. These interactions between Pb and P that alter Pb speciation may be important determinants of the bioavailability of Pb ingested in soil.
URLs/Downloads:
DOI: Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse