You are here:
20190825 - High-throughput experimental and computational technologies at the National Center for Computational Toxicology (ACS Fall 2019)
Citation:
Grulke, C., A. Williams, J. Wambaugh, R. Judson, K. Houck, AND K. Friedman. 20190825 - High-throughput experimental and computational technologies at the National Center for Computational Toxicology (ACS Fall 2019). American Chemical Society Fall Meeting, San Diego, CA, August 25 - 29, 2019. https://doi.org/10.23645/epacomptox.9902693
Impact/Purpose:
Presentation to be given to the fall meeting of the American Chemical Society in August 2019. This presentation will provide an overview of the CompTox Chemicals Dashboard and how this freely available community resource provides access to experimental and predicted data generated within the EPA’s National Center for Computational Toxicology, and is an information hub for data aggregated from public databases. This includes specific efforts to aggregate data associated with pesticides and the generation of large volumes of in vitro bioactivity data associated with 100s of assays.
Description:
The U.S. Environmental Protection Agency (EPA) is faced with the challenge of efficiently evaluating chemical safety often with access to only sparse toxicity data. The increasing number of chemicals found in commerce and the environment, together with the time and resource requirements for traditional toxicity testing and exposure characterization, requires new approaches to be developed. In 2005, EPA embraced computational toxicology (CompTox) to deliver results and applications across a broad range of environmental health problems. This work includes 1) the Toxicity Forecaster (ToxCast) project for in vitro high-throughput screening (HTS) of environmental chemicals; 2) high-throughput toxicokinetics (HTTK) and 3) high-throughput transcriptomics (HTTr) for cost-efficient screening of thousands of chemicals. One aspect of this work has been the delivery of a number of web-based “dashboards” providing access to experimental and predicted data ensuring community access to data streams that can be of value to researchers. This presentation will provide an overview of the CompTox Chemicals Dashboard and how this freely available community resource provides access to experimental and predicted data generated within the EPA’s National Center for Computational Toxicology, and is an information hub for data aggregated from public databases. This includes specific efforts to aggregate data associated with pesticides and the generation of large volumes of in vitro bioactivity data associated with 100s of assays. This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.
URLs/Downloads:
DOI: 20190825 - High-throughput experimental and computational technologies at the National Center for Computational Toxicology (ACS Fall 2019)
GRULKE_HIGH-THROUGHPUT EXPERIMENTAL AND COMPUTATIONAL TECHNOLOGIES AT NCCT.PDF (PDF, NA pp, 3350.765 KB, about PDF)