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Talk for Concawe- Environmental Science for EU refining group, June 28, 2019- Webcast
Citation:
Ulrich, E., J. Sobus, C. Grulke, A. Richard, E. Schymanski, S. Newton, M. Strynar, K. Mansouri, R. Singh, J. McCord, K. Isaacs, J. Wambaugh, AND A. Williams. Talk for Concawe- Environmental Science for EU refining group, June 28, 2019- Webcast. WEBCAST: Talk for Concawe- Environmental Science for EU refining group, webinar, June 28, 2019.
Impact/Purpose:
Non-targeted analysis (NTA) strives to detect and identify a wide range of chemicals without preconceived target list or standards. Such efforts can be applied to and use a variety of exposure science efforts, including basic research into the technique (ENTACT), informatics tools (CompTox Chemicals Dashboard), complex mixtures (UVCBs) and pairing exposure to effects (EDA). Approximately 30 laboratories worldwide are characterizing their non-targeted analysis approaches. Because the instrumental and data processing methods vary significantly, so do performance metrics. Physicochemical properties are statistically different between instrumental method choices (gas vs. liquid chromatography, electrospray vs. atmospheric pressure chemical ionization) showing the techniques cover different portions of chemical space. Current and future NTA research areas are also linked to larger scientific efforts within the exposure community at EPA.
Description:
Non-targeted analysis (NTA) strives to detect and identify a wide range of chemicals without preconceived target list or standards. This presentation discusses several applications and planned projects using NTA to better understand and characterize the exposome. These projects include EPA's Non-Targeted Analysis Collaborative Trial (ENTACT); recent and future improvements to the Comptox Chemicals Dashboard; and planned activities to better characterize UVCBs including effects of individual components. These research activities are also linked to larger scientific efforts within the exposure community at EPA.