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Within- and Between-individual Temporal Variability in Spot Urine Caffeine and Caffeine Metabolite Concentrations in 50 North Carolina Adults ver a Six
Citation:
Rybak, M., C. Pao, M. Sternberg, M. Morgan, AND J. Sobus. Within- and Between-individual Temporal Variability in Spot Urine Caffeine and Caffeine Metabolite Concentrations in 50 North Carolina Adults ver a Six. Nutrition 2019, Baltimore, MD, June 08 - 11, 2019.
Impact/Purpose:
The majority of studies examining caffeine as a risk factor in human health rely upon dietary intake data to assess exposure. Intake variability associated with major dietary sources (e.g. coffee) as well as capturing intake from emerging sources (e.g. energy drinks) presents challenges. Measures of caffeine and caffeine metabolite excretion in the urine are associated with caffeine intake and may be suitable as caffeine intake biomarkers [1]. Little is known regarding the temporal variability of these measures in spot urine samples, and better understanding of this behavior would help in determining the number of samples needed to accurately represent biomarker concentration over a given time period.
Description:
The majority of studies examining caffeine as a risk factor in human health rely upon dietary intake data to assess exposure. Intake variability associated with major dietary sources (e.g. coffee) as well as capturing intake from emerging sources (e.g. energy drinks) presents challenges. Measures of caffeine and caffeine metabolite excretion in the urine are associated with caffeine intake and may be suitable as caffeine intake biomarkers [1]. Little is known regarding the temporal variability of these measures in spot urine samples, and better understanding of this behavior would help in determining the number of samples needed to accurately represent biomarker concentration over a given time period.
