You are here:
Practical applications of New Approach Methodologies (NAM) in chemical safety assessment: applying US EPA tools/approaches in practice
Citation:
Patlewicz, G. Practical applications of New Approach Methodologies (NAM) in chemical safety assessment: applying US EPA tools/approaches in practice. CE Workshop Proposal for Society for Risk Analysis annual meeting, Arlington, VA, December 08 - 12, 2019.
Impact/Purpose:
Continuing Education workshop proposal submitted to the Society for Risk Assessment 2019 annual meeting held December 2019. This hands-on training CE course will provide attendees with a working knowledge on how to effectively access and exploit the many different data streams available in the EPA’s CompTox Chemicals Dashboard to support different regulatory purposes. The training is targeted towards regulatory scientists, students and researchers. The CE course will include an overview of the dashboard itself and its main capabilities, before providing more in-depth training through case studies for each data stream (e.g. interpretation of ToxCast high-throughput screening data, use of read-across, generating QSAR predictions). A final case study will showcase how to integrate all the different data streams together for chemical safety assessment purposes.
Description:
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data driven approaches that integrate chemistry, exposure and biological data. These efforts have produced rich data collections of chemical and bioassay data and resulted in the development of numerous software tools for delivering the data to the community. The CompTox Chemicals Dashboard has been developed as a web-based application which integrates various data sources to enable a one-stop resource for identifying available information for chemicals. It provides access to ~875,000 chemicals and associated experimental and predicted properties, high-throughput screening data from the ToxCast project, links to existing Adverse Outcome Pathways (AOPs) and product and functional use data for thousands of chemicals. Flexible searching supports simple chemical identifier look-up based on chemical name and CAS registry number (CASRN) and structure identification is feasible using mass and formula-based searching to support non-targeted analyses using mass spectrometry. Batch-based searching enables the user to look up large collections of chemical data using name, CASRN, InChIkeys and other identifiers and to export associated information in standard file formats. Other developments provide a means to search for literature information, make real-time predictions using different quantitative structure-activity relationship (QSAR) models and read-across predictions through a flexible workflow. The Dashboard provides a foundation from which many of its new applications for use within the Agency and by the research community have been developed. This abstract does not necessarily reflect U.S. EPA policy.