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High Throughput Toxicokinetics for Rapid Risk Prioritization
Citation:
Wambaugh, J. High Throughput Toxicokinetics for Rapid Risk Prioritization. Presented at Optimizing Drug Metabolism & Pharmacokinetics, Boston, MA, June 19 - 20, 2018.
Impact/Purpose:
This is a presentation as part of the conference “Optimizing Drug Metabolism & Pharmacokinetics” on June 19-20th in Boston, MA.
Description:
Chemical prioritization based on potential human health hazard requires exposure, toxicity, and toxicokinetic (TK) data which are unavailable for thousands of chemicals. To provide TK estimates, high throughput, in vitro TK (HTTK) pharmaceutical methods have been adapted for environmental chemicals. Systematically comparing HTTK predictions to in vivo data allows quantification of model uncertainty enabling chemical prioritization. This abstract does not necessarily reflect U.S. EPA policy.