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Meeting Materials for the NAS Meeting to Evaluate the Updated Problem Formulation and Systematic Review Protocol for the Inorganic Arsenic (Ias) IRIS Assessment Document (Jul 2019)
Citation:
Meeting Materials for the NAS Meeting to Evaluate the Updated Problem Formulation and Systematic Review Protocol for the Inorganic Arsenic (Ias) IRIS Assessment Document (Jul 2019).
Impact/Purpose:
N/A
Description:
In July 2019, an NAS ad hoc committee will conduct a peer review of the revised scope of the assessment and determine whether the proposed methods are appropriate to synthesize the scientific evidence and develop conclusions. Given the size and complexity of the evidence base for this chemical, input on the scope of this assessment has been sought from the National Academy of Sciences, Engineering, and Medicine (NAS), EPA Program and Regional Offices, other federal agencies, and public stakeholders to help focus the objectives of the assessment and ensure it is transparently conducted. The Updated Problem Formulation and Protocol summarizes the Agency's need for the assessment and presents the refined focus based on problem formulation activities conducted since the last assessment plan released to the NAS in 2015.
URLs/Downloads:
Poster 1: Systematic Review Methods and Hazard Characterization for the Updated Problem Formulation and Protocol for the Inorganic Arsenic (iAs) IRIS Assessment (PDF, 1 pp, 252 KB, about PDF)Poster 2: Building an Adverse Outcome Pathway Network for Arsenic-Induced Bladder Cancer (PDF, 1 pp, 773 KB, about PDF)
Poster 3: Evaluation of a Physiologically-based Pharmacokinetic (PBPK) Model for Inorganic Arsenic (iAs) Exposure Using Data from Two Diverse Human Populations (PDF, 1 pp, 624 KB, about PDF)
Poster 4: Analyzing Study-Specific Estimates of Exposures Associated with a Defined Relative Risk vs U.S. Background Exposure (RRBs) for Inorganic Arsenic (iAs) Health Outcome (PDF, 1 pp, 728 KB, about PDF)
Poster 5: The Application of Model Averaging Methods to Assess the Suitability of Taiwanese Studies for Predicting U.S. Bladder and Lung Cancer Risk from Inorganic Arsenic (iAs) Intake (PDF, 1 pp, 813 KB, about PDF)
Poster 6: Bayesian Hierarchical Meta-Regression of Epidemiologic Studies: Dose and Response Pre-Analysis (Part 1) (PDF, 1 pp, 551 KB, about PDF)
Poster 7: Bayesian Hierarchical Meta-Regression of Epidemiologic Studies: Dose-Response Modeling and Target Population Predictions (PDF, 1 pp, 759 KB, about PDF)
U.S.EPA Updated Problem Formulation and Scoping (for the IRIS Assessment of Inorganic Arsenic) (PDF, 16 pp, 1038 KB, about PDF)
U.S.EPA Systematic Review Methods Used to Prioritize Health Outcome (PDF, 25 pp, 3345 KB, about PDF)
U.S.EPA Inorganic Arsenic IRIS Dose-Response Analyses (PDF, 31 pp, 1478 KB, about PDF)
Introduction and Role of the Protocol in the IRIS Systematic Review Process (PDF, 7 pp, 430 KB, about PDF)
Summary Table for Comments Received on iAs Protocol for Transmittal to the NAS Committee (PDF, 21 pp, 427 KB, about PDF)