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Comment on: Dong et al. (2017) “Issues raised by the reference doses for perfluorooctonate sulfonate and perfluorooctanoic acid.”
Citation:
Wambaugh, J. Comment on: Dong et al. (2017) “Issues raised by the reference doses for perfluorooctonate sulfonate and perfluorooctanoic acid.”. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 121(2):1372-1374, (2018). https://doi.org/10.1016/j.envint.2018.10.048
Impact/Purpose:
A recent article in Environment International by Dong et al. (2017) includes commentary on pharmacokinetic (PK) modeling and associated statistical analysis of two environmental contaminants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Each chemical was recently (2016) evaluated by the U.S. EPA in separate “Drinking Water Health Advisory” reports. In Section 4 of Dong et al. (2017), “TK models for PFOS and PFOA,” the authors raise several points which provide opportunity for clarification.
Description:
A recent article in Environment International by Dong et al. (2017) includes commentary on pharmacokinetic (PK) modeling and associated statistical analysis of two environmental contaminants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Each chemical was recently (2016) evaluated by the U.S. EPA in separate “Drinking Water Health Advisory” reports. In these documents, Bayesian methods were used to estimate species-specific values for the empirical Andersen et al. (2006) PK model. Using the estimated values, the Andersen et al. (2006) model showed consistency between the plasma concentrations associated with toxic effects in animals of different species. We use the term “PK” for consistency with past work, but for this commentary PK is equivalent to “toxicokinetics (TK)” as used in the Dong et al. (2017) article. In Section 4 of Dong et al. (2017), “TK models for PFOS and PFOA,” the authors raise several points which provide opportunity for clarification.
URLs/Downloads:
DOI: Comment on: Dong et al. (2017) “Issues raised by the reference doses for perfluorooctonate sulfonate and perfluorooctanoic acid.”