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Application of AOPs to Developmental Outcomes
Citation:
Knudsen, T. Application of AOPs to Developmental Outcomes. Teratology Society's 59th Annual Meeting, San Diego, CA, June 22 - 26, 2019. https://doi.org/10.23645/epacomptox.8179184
Impact/Purpose:
Presentation given at Teratology Society's 59th Annual Meeting Lunch and Learn Mini Course on Adverse Outcome Pathways (AOPs) June 2019
Description:
AOP-based ontologies provide the necessary structure for quantitative prediction of cellular and tissue responses to molecular perturbation(s). For DevTox, this can be demonstrated by an AOP framework for embryonic vascular disruption represented in the OECD AOP-KB (Aop43). Because the ‘angiogenic cycle’ is responsive to diverse genetic and physiological signals, Aop43 provides a kernel for co-opting larger AOP networks. Computer modeling and simulation puts all key events into motion enabling a new way to predictively model multicellular complexity in a self-organizing ‘virtual’ system.
URLs/Downloads:
DOI: Application of AOPs to Developmental Outcomes
TS-AM19_PPT_KNUDSEN_CASE_V3_M.PDF (PDF, NA pp, 3998.932 KB, about PDF)