Science Inventory

Application of AOPs to Developmental Outcomes

Citation:

Knudsen, T. Application of AOPs to Developmental Outcomes. Teratology Society's 59th Annual Meeting, San Diego, CA, June 22 - 26, 2019. https://doi.org/10.23645/epacomptox.8179184

Impact/Purpose:

Presentation given at Teratology Society's 59th Annual Meeting Lunch and Learn Mini Course on Adverse Outcome Pathways (AOPs) June 2019

Description:

AOP-based ontologies provide the necessary structure for quantitative prediction of cellular and tissue responses to molecular perturbation(s). For DevTox, this can be demonstrated by an AOP framework for embryonic vascular disruption represented in the OECD AOP-KB (Aop43). Because the ‘angiogenic cycle’ is responsive to diverse genetic and physiological signals, Aop43 provides a kernel for co-opting larger AOP networks. Computer modeling and simulation puts all key events into motion enabling a new way to predictively model multicellular complexity in a self-organizing ‘virtual’ system.

URLs/Downloads:

https://doi.org/10.23645/epacomptox.8179184   Exit

TS-AM19_PPT_KNUDSEN_CASE_V3_M.PDF   (PDF,NA pp, 3998.932 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Product Published Date: 06/26/2019
Record Last Revised: 05/28/2019
OMB Category: Other
Record ID: 345170

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY