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The EPA CompTox Chemicals Dashboard – An integration hub for data supporting computational toxicology (NURA)
Citation:
Williams, A. The EPA CompTox Chemicals Dashboard – An integration hub for data supporting computational toxicology (NURA). Presented at New Approach Methodologies Use for Regulatory Application (NURA) Training Meeting, Gaithersburg, MD, May 21 - 22, 2019. https://doi.org/10.23645/epacomptox.8179139
Impact/Purpose:
Companies submitting information to EPA under TSCA are learning how to incorporate New Approach Methodologies (NAMs). Presentation given at New Approach Methodologies Use for Regulatory Application (NURA) Training Meeting May 2019.
Description:
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This involves computational and data-driven approaches that integrate chemistry, exposure and biological data. The National Center for Computational Toxicology (NCCT) has measured, assembled and delivered an enormous quantity and diversity of data for the environmental sciences, including high-throughput in vitro screening data, in vivo and functional use data, exposure models and chemical databases with associated properties. The CompTox Chemicals Dashboard is a web-based application providing access to data associated with ~875,000 chemical substances. New data are continuously added to the database on an ongoing basis, along with registration of new and emerging chemicals. This includes data extracted from the literature, identified by our analytical labs, and otherwise of interest to support specific research projects to the agency. By adding these data, with their associated chemical identifiers (names and CAS Registry Numbers), the dashboard uses linking approaches to allow for automated searching of PubMed, Google Scholar and an array of public databases. This presentation will provide an overview of the CompTox Chemicals Dashboard, how it has developed into an integrated data hub for environmental data, and how it can be used for the analysis of emerging chemicals in terms of sourcing related chemicals of interest, and deriving read-across as well as QSAR predictions in real time. This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.
URLs/Downloads:
DOI: The EPA CompTox Chemicals Dashboard – An integration hub for data supporting computational toxicology (NURA)
WILLIAMS_NURA_V2_FINAL.PDF (PDF, NA pp, 4382.862 KB, about PDF)