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Systematic Review Protocol for the Perfluorohexanesulfonic Acid (PFHxS) IRIS Assessment (Preliminary Assessment Materials)
Citation:
U.S. EPA. Systematic Review Protocol for the Perfluorohexanesulfonic Acid (PFHxS) IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-19/050, 2019.
Impact/Purpose:
This document presents a draft assessment plan for the PFHxS assessment that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in the Fall of 2019 and that will define the scope and approach of the IRIS assessment for these chemicals.
Description:
In November 2019, EPA released the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments for a 45-day public comment period. As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
URLs/Downloads:
An Update to the Systematic Review Protocol for the PFBA, Pfhxa, Pfhxs, PFNA, and PFDA IRIS Assessments (Jan 2021) (PDF, 208 pp, 3416 KB, about PDF)An Update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (Oct 2020) (PDF, 203 pp, 3308 KB, about PDF)
Errata Sheet Pertaining to the July 2020 Update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (Sep 2020) (PDF, 1 pp, 108 KB, about PDF)
An Update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (July 2020) (PDF, 203 pp, 3315 KB, about PDF)
Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (Oct 2019) (PDF, 197 pp, 3000 KB, about PDF)
Primary Literature Search References Sorted By Author (PFHxS)
FR Notice: Nov 8, 2019
EPA-HQ-ORD-2019-0275