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Use of GenRA to Assist in Read-Across
Citation:
Patlewicz, G. Use of GenRA to Assist in Read-Across. Presented at Office of Environmental Health Hazard Assessment (OEHHA) of Cal EPA Workshop on Read-Across, Oakland, CA, May 02 - 03, 2019. https://doi.org/10.23645/epacomptox.8127164
Impact/Purpose:
Presentation to the Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency (CalEPA) Workshop on Understanding and Applying Read-Across for Human Health Risk Assessment May 2019.
Description:
Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across. A source analogue is a chemical that has been identified as an appropriate chemical for use in a read-across based on similarity to the target chemical and existence of relevant data. The EPA's National Center for Computational Toxicology has a Generalized Read-Across workflow implemented into the CompTox Chemicals Dashboard. The approach allows users to identify analogues in different ways, quickly assess the availability of relevant in vivo data for those analogues and visualize these in a data matrix to evaluate the consistency and concordance of the available experimental data for those analogues before making a GenRA prediction. Predictions can be exported into a tab-separated value (TSV) or Excel file for additional review and analysis (e.g. doses of analogues associated with production of toxic effects). GenRA offers a new capability of making reproducible read-across predictions in an easy-to-use interface. The views expressed in this presentation are those of the author and do not necessarily reflect the views or policies of the US EPA.
URLs/Downloads:
DOI: Use of GenRA to Assist in Read-Across
PATLEWICZ_GENRA_CALEPA_240419.PDF (PDF, NA pp, 3491.524 KB, about PDF)