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PFAS Prioritisation for Targeted Testing
Citation:
Patlewicz, G. PFAS Prioritisation for Targeted Testing. Presented at Office of Environmental Health Hazard Assessment (OEHHA) of Cal EPA Workshop on Read-Across, Oakland, CA, May 02 - 03, 2019. https://doi.org/10.23645/epacomptox.8127137
Impact/Purpose:
Presentation to the Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency (CalEPA) Workshop on Understanding and Applying Read-Across for Human Health Risk Assessment May 2019. Session Title: Read-Across Principles in Testing and Assessing PFAS Chemicals.
Description:
What are Per-and Polyfluoroalkyl Substances (PFAS)? Thousands of PFAS are associated with the production of industrial and consumer products. They are a concern due to: 1) Known or suspected toxicity, especially for PFOS and PFOA, 2) Bioaccumulation, 3) Long half lives (e.g., several years), especially in humans, 4) Mobility - shorter chain PFAS tend to be highly mobile, longer chain PFAS less mobile. What are PFAS of potential interest to the EPA? In the steps of maximising read-across, known information on the property of a substance (source chemical) is used to make a prediction of the same property for another substance (target chemical) that is considered “similar” i.e. endpoint & often study specific. Use of information for “PFAS source substances” is used to infer (read-across) missing information for a related similar PFAS target. Next steps involve complete targeted testing, and data analysis per NAM technology and integrated across technologies to inform both read-across efforts and structural categories, and to work to extend objective structural categories to facilitate harmonisation across different inventories. The views expressed in this presentation are those of the author and do not necessarily reflect the views or policies of the US EPA.
URLs/Downloads:
DOI: PFAS Prioritisation for Targeted Testing
PATLEWICZ_PFAS_CALEPA_230419.PDF (PDF, NA pp, 3992.259 KB, about PDF)