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Approaches to Hazard and Dose-Response Assessment of PFAS: PFBS Example
Citation:
Lambert, J. Approaches to Hazard and Dose-Response Assessment of PFAS: PFBS Example. Presented at Office of Environmental Health Hazard Assessment (OEHHA) of Cal EPA Workshop on Read-Across, Oakland, CA, May 02 - 03, 2019. https://doi.org/10.23645/epacomptox.8126891
Impact/Purpose:
Presentation to the Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency (CalEPA) Workshop on Understanding and Applying Read-Across for Human Health Risk Assessment May 2019.
Description:
Depending on who you talk to, there are anywhere from 20K to >80K chemicals currently in the environment/commerce; several thousand are PFAS compounds. Collectively, across our global community of toxicology and risk assessment practice, only a small fraction of those chemicals have been assessed for toxicity; current data availability for most PFAS is limited. For problem formulations associated with protection of human health and the natural environment, higher throughput of qualitative and quantitative information for PFAS is paramount. Over the past decade, several reports, books, resource documents, etc. have been published regarding the use of New Approach Methods (NAM) across the human health risk assessment paradigm. Numerous labs, centers, workgroups, and initiatives across federal, private, and academic institutions have been formed to advance NAM and Computational Toxicology platforms. This talk provides an overview of the EPA's NAM/CompTox Toolbox of techniques to enable greater discovery of chemical hazards. The views in this presentation are those of the author and do not necessarily represent the views or policies of the US EPA.
URLs/Downloads:
DOI: Approaches to Hazard and Dose-Response Assessment of PFAS: PFBS Example
CALEPA_OEHHA_PFAS_WORKSHOP_LAMBERT_SESSION 3_V2.PDF (PDF, NA pp, 3134.973 KB, about PDF)