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Systematic Review Protocol for the PFAS IRIS Assessments (2021)
EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. The IRIS Program is using the updated systematic review protocol to develop five separate PFAS IRIS assessments.
Citation:
U.S. EPA. Systematic Review Protocol for the PFAS IRIS Assessments (2021). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-19/050, 2019.
Impact/Purpose:
This document presents a draft assessment plan for 5 PFAS assessments that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in the Fall of 2019 and that will define the scope and approach of the IRIS assessment for these chemicals.
Description:
The protocol presents the methods for conducting the systematic reviews and dose-response analyses for development of a draft IRIS assessment for five per- and polyfluoroalkyl substances (PFAS) assessments including: perfluorodecanoic acid (PFDA; CASRN 335-76-2), perfluorononanoic acid (PFNA; CASRN 375-24-4), perfluorohexanoic acid (PFHxA, CASRN 307-24-4), perfluorohexanesulfonic acid (PFHxS, CASRN 355-46-4), and perfluorobutanoic acid (PFBA, CASRN 375 22 4), and their related salts which are all members of the group per and polyfluoroalkyl substances (PFAS). These five toxicity assessments are being developed according to the scope and methods outlined in this protocol built upon several other PFAS assessments that have already been developed by the EPA. It includes a summary of why these specific PFAS were prioritized for evaluation, description of the objectives and specific aims of the assessments, draft PECO (Populations, Exposures, Comparators, and Outcomes) criteria, and identification of key areas of scientific complexity.
URLs/Downloads:
An Update to the Systematic Review Protocol for the PFBA, Pfhxa, Pfhxs, PFNA, and PFDA IRIS Assessments (Jan 2021) (PDF, 208 pp, 3416 KB, about PDF)An Update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (Oct 2020) (PDF, 203 pp, 3308 KB, about PDF)
Errata Sheet Pertaining to the July 2020 Update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (Sep 2020) (PDF, 1 pp, 108 KB, about PDF)
An Update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (July 2020) (PDF, 203 pp, 3315 KB, about PDF)
Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments (Oct 2019) (PDF, 197 pp, 3480 KB, about PDF)
FR Notice: Nov 8, 2019
Docket ID#: EPA-HQ-ORD-2019-0275
Learn more about Per- and polyfluoroalkyl substances
EPA's PFAS Action Plan
Risk Management for Per- and Polyfluoroalkyl Substances (PFAS) under TSCA
List of HERO Project pages for PFAS
GenX and PFBS Draft Toxicity Assessments
Systematic Review Protocol for the Perfluorobutanoic Acid (PFBA) IRIS Assessment
Systematic Review Protocol for the Perfluorodecanoic Acid (PFDA) IRIS Assessment
Systematic Review Protocol for the Perfluorononanoic Acid (PFNA) IRIS Assessment
Systematic Review Protocol for the Perfluorohexanoic Acid (PFHxA) IRIS Assessment
Systematic Review Protocol for the Perfluorohexanesulfonate (PFHxS) IRIS Assessment