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US-EPA CompTox Chemicals Dashboard: Bioactivity Data for Endocrine Assays (EDSP)
Citation:
Williams, A. AND K. Friedman. US-EPA CompTox Chemicals Dashboard: Bioactivity Data for Endocrine Assays (EDSP). Presented at Endocrine Disruptor Screening Program Meeting, RTP, NC, April 05, 2019. https://doi.org/10.23645/epacomptox.8126246
Impact/Purpose:
The support of multiple dashboards is inefficient and has required significant overhead. Improved efficiencies and functionality enhancements have resulted from migrating functionality in the EDSP21 and ToxCast dashboards to the CompTox Chemicals Dashboard. This migration was synchronized to the release of the invitroDBv3.1 data expanding coverage of both the number of chemicals and assays available. The CompTox Chemicals Dashboard provides access to data associated with 875k chemical substances. Integrating data from a series of databases into a simple to use web-based interface, the dashboard provides access to experimental and predicted physicochemical properties and fate and transport data, in vivo hazard and exposure data. The dashboard provides real-time prediction for both property and toxicity endpoints, batch searching for thousands of chemicals and new approaches to navigate through bioactivity data. This includes a segregated list of the EDSP universe of chemicals and assays associated with the invitroDBv3.1 release of data.
Description:
EPA’s National Center for Computational Toxicology is developing automated workflows for curating large databases within the DSSTox project and for providing accurate linkages of data to chemical structures, exposure, and hazard data. The data are made available via the EPA’s CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard), a publicly accessible website providing access to data for ~875,000 chemical substances, the majority of these represented with chemical structures. The web application delivers a wide array of computed and measured physicochemical properties, in vitro high-throughput screening data and in vivo toxicity data, and linkages to a growing list of literature, toxicology, and analytical chemistry websites. The dashboard version 3:March 2019 release includes support for the invitroDBv3.1 data release2 and includes new functionality to interact with all ToxCast and Tox21 data with the intention of replacing the previously available EDSP21 and ToxCast dashboards. The previous dashboards will be retired in summer 2019. This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.
URLs/Downloads:
DOI: US-EPA CompTox Chemicals Dashboard: Bioactivity Data for Endocrine Assays (EDSP)
EDSP_APRIL5_DASHBOARD_WILLIAMS_POSTER_FINAL_KPF.PDF (PDF, NA pp, 770.056 KB, about PDF)