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Evidence Based Toxicokinetics
Citation:
Wambaugh, J. Evidence Based Toxicokinetics. Presented at Society of Toxicology Annual Meeting, Baltimore, Maryland, March 13, 2019. https://doi.org/10.23645/epacomptox.8101190
Impact/Purpose:
This is a presentation given to the 2019 Society of Toxicology's Computational Toxicology Specialty Section as part of receiving the CompTox Specialty Section Paper of the Year award.
Description:
Toxicokinetics (TK) describes the Absorption, Distribution, Metabolism, and Excretion (ADME) of a chemical by the body. TK relates external exposures to internal tissue concentrations of chemical. Most industrial chemicals, ranging from industrial waste to dyes to packing materials, are covered by the Toxic Substances Control Act (TSCA) and regulated by EPA. New approach methodologies (NAMs) are being considered to inform prioritization of chemicals for testing and evaluation (Kavlock et al., 2018).
URLs/Downloads:
DOI: Evidence Based Toxicokinetics
WAMBAUGH_SOT_CTSS-AWARD-031319-4.PDF (PDF, NA pp, 2034.324 KB, about PDF)