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Chapter 24 - Can Computational Models Be Used to Assess the Developmental Toxicity of Environmental Exposures?
Citation:
Knudsen, T. Chapter 24 - Can Computational Models Be Used to Assess the Developmental Toxicity of Environmental Exposures? Chapter 24, Teratology Primer, Third Edition. John Wiley & Sons Inc, Malden, MA, , 1-5, (2018).
Impact/Purpose:
This chapter updates the Teratology Primer (3rd edition, eds B Hales, A Scialli, M Tassinari) published by the Teratology Society aimed for medical/dental/graduate students. This chapter helps students understand the science need and challenge for building and testing computational (in silico) models for quantitative risk assessment of prenatal developmental toxicity.
Description:
Computational models can translate in vitro data from HTS testing platforms to potential in vivo outcomes. Much effort is being expended today to realize this challenge for the future. EPA’s Virtual Embryo research program is building and testing computational (in silico) models that may make high-throughput screening data useful in a quantitative risk assessment of developmental toxicity (http://www.epa.gov/ncct/v-Embryo/).