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Updated Problem Formulation and Systematic Review Protocol for the Inorganic Arsenic IRIS Assessment
EPA announced the release of the Updated Problem Formulation and Systematic Review Protocol for the IRIS inorganic Arsenic Assessment for a 30-day public comment period. The protocol was discussed with the National Academy of Sciences, Engineering, and Medicine (NAS) at a public meeting on July 16, 2019. Public comments received on the protocol are now available.
Citation:
U.S. EPA. Updated Problem Formulation and Systematic Review Protocol for the Inorganic Arsenic IRIS Assessment. U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-19/049, 2019.
Impact/Purpose:
This document presents a draft assessment plan for inorganic arsenic that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in the spring of 2019 and that will define the scope and approach of the IRIS assessment of this chemical.
Description:
In May 2019, EPA released the Updated Problem Formulation and Systematic Review Protocol for the Inorganic Arsenic IRIS Assessment for a 30-day public comment period. The IRIS Program is updating its 1988 Toxicological Review of Inorganic Arsenic. Given the size and complexity of the evidence base for this chemical, input on the scope of this assessment has been sought from the National Academy of Sciences, Engineering, and Medicine (NAS), EPA Program and Regional Offices, other federal agencies, and public stakeholders to help focus the objectives of the assessment and ensure it is transparently conducted. On July 16, 2019, an NAS ad hoc committee will evaluate the revised scope of the assessment and determine whether the proposed methods are appropriate to synthesize the scientific evidence and develop conclusions.
URLs/Downloads:
Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment (Supplemental Information - Appendix_A, 2023) (PDF, 186 pp, 3798 KB, about PDF)Updated Problem Formulation and Systematic Review Protocol for the Inorganic Arsenic IRIS Assessment (2019) (PDF, 176 pp, 2474 KB, about PDF)
Errata Sheet (Jun 2019) for the Updated Problem Formulation and Systematic Review Protocol for Inorganic Arsenic IRIS Assessment (PDF, 1 pp, 96 KB, about PDF)
Charge for the National Academies of Sciences Review of the Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment (PDF, 3 pp, 309 KB, about PDF)
Summary of Public Comments Received on IRIS Inorganic Arsenic Protocol for Transmittal to NAS Committee (Jul 2019) (PDF, 21 pp, 430 KB, about PDF)
Primary Literature Search References Sorted By Author (Inorganic Arsenic)
EPA-HQ-ORD-2012-0830
FR Notice: May 28, 2019